Fermenter Bioreactor Crystallizer

EEI has designed and manufactured Bioreactor vessel of 7.5 kl capacity at 20 kg/cm2 pressure with 316SS material for a pharmaceutical company.

Fermenter is a type of bioreactor. Bioreactor is the vessel that facilitates various types of biochemical reactions. Crystallizers are chemical processing equipment for liquid-solid separation.

The main function of Bioreactor and Fermenter is to provide agitation, aeration, sterility, regulation of factors like temperature, pH, pressure, nutrient feeding, liquid level, etc. and allow withdrawal of cells or the medium. Crystallizers are used in industry to achieve liquid-solid separation. Crystallizers are capable of generating high purity products with relatively low energy input.

What is Fermenter?

The fermenter is a type of bioreactor (stirred or non-stirred tanks) which uses fungi or bacteria for the fermentation of ethanol or lactic acid. The fermenter is the vessel that facilitates fermentation. Fermenters can be operated as continuous or batch-culture systems. Hence, a fermenter operates under anaerobic conditions. In continuous culture, nutrients are continuously fed into the fermentation vessel. This allows the cells to ferment indefinitely. Also, the fermenter is capable of providing optimal growth conditions such as temperature to microorganisms.

What is Industrial fermentation?

Fermentation: Metabolic reactions are the chemical processes that are necessary to generate energy in (mainly microbial) cells in all living organisms, which help them complete their life cycles.

Industrial fermentation is the use of microorganisms on a large scale, to produce commercial products like such as pickles, cheese, wine, beer, biological insecticides, organic pesticides antibiotics, vitamins, amino acids, solvents and biofuels like ethanol & biogas. Industrial fermentation is a part of many industries, including microbiology, food, pharmaceutical, biotechnology, and chemical.

Industrial Fermenters are Bioreactor vessels that maintain optimal conditions for the growth of micro-organisms used in large scale fermentation and in the commercial production of antibiotics and fertilizer.

The purpose of a fermenter is to provide controllable conditions for the growth of cells. The cell growth is monitored and controlled for the various parameters such as pH, temperature, nutrients, fluid flow, and other variables.

There are two kinds of fermenters, those for anaerobic processes (oxygen-free) and aerobic processes. Anaerobic fermenters can be as simple as stainless-steel tanks or barrels with equipment to remove heat generated during the fermentation process. Aerobic fermentation is the most common in the industry. Aerobic fermenters systems are designed to provide mixing and adequate aeration. Stainless steel and jacketed vessel with sparges and agitators having turbine blades are designed for numerous applications and supplied to pharmaceutical and chemical industries and fertiliser industry. Oxygen transfer and dispersion are provided by stirring with impellers or air sparging.

Anaerobic fermentors do not require special equipment except for the removal of heat generated during the fermentation process.

What is a Bioreactor?

Bioreactor is the vessel that facilitates various types of biochemical reactions.

Bio reactor is a closed vessel with adequate arrangement for cell growth under controlled conditions for aeration, agitation, temperature and pH control, and drain or overflow vent to remove the waste biomass of cultured microorganisms along with their products. Small laboratory scale Bioreactors are from five to ten milliliters and the large industrial scale Bioreactors can also be 500,000 liters.

Bioreactor design

At EEI we customize for the material and application. All bioreactors are heterogeneous systems dealing with two or more phases, e.g., liquid, gas, solid. Fermentation necessitates the efficient transfer of mass, heat, and momentum from one phase to the other.

The special features of our bioreactors are as follows:

  1. Agitators for mixing of cells and medium. The Turbine Agitators with blades in reactors are used for efficient mixing, suspending and blending applications. Stainless steel agitators are sturdy, aids homogenous liquid mixing, improvises the reaction rate of chemical substances, enhances the heat transfer, high stirring & blending capacity. Reactor vessels with turbine blades have been manufactured and supplied for fertiliser & dyes industries, food industry.  The industrial agitators/ impellers are of flat blade turbine, disk flat blade turbine and pitched blade turbine.
  2. Aerobic fermenters have Aeration for O2supply.
  3. Regulators for temperature, pH, pressure, nutrient feeding, liquid level etc.,
  4. Maintenance of sterility for sterilization.
  5. In continuous fermenters provisions for withdrawal of cells/medium.
  6. Jacketed reactor vessels are used with steam for heating or cooling in the chemical industry and pharmaceutical industry basically due to its temperature resistance and corrosion resistance.
  7. High-Pressure reactors are manufactured with top dish and bolt for catalysis, hydrogenation reaction, petrochemical industry, and pharmaceutical industry.

 What is Crystallizer?

Crystallizers are used in the chemical and food industry to achieve liquid-solid separation.

Forced-circulation crystallization is evaporative crystallizers which are the most widely used crystallization method in the industry. They create a super-saturated solution by evaporating the solvent of a saturated solution. The solute of this supersaturated solution then cools, forming crystals. Forced-circulation crystallizers are commonly used to produce salts and chemicals in industry.

Bioreactor System

The combination of a bioreactor and crystallizer as bioreactor system.

This bioreactor system in which an enzymatic reaction and product crystallization occurs simultaneously has high level of productivity with decreased operating time.

The process of biochemical reactions in Bioreactor the crystallization equipment is used for the evaporation and crystallization of the products.

contact@ee2i.com with the following details for techno- commercial offer
Medium- pressure, temperature, capacity, viscosity
Availability of heating medium